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Article

No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2006

Lindqvist M, Hindorf U, Almer S, Söderkvist P, Ström M, Hjortswang H, Peterson C

Abstract excerpt

The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions. Sixty patients with ulcerative colitis or Crohn's disease were included in this open and prospective...

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Share to Antimetabolites
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Inflammatory Bowel Diseases

Share to Mercaptopurine

Share to Methyltransferases

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Source

Identifiers

PMID: 17065060
DOI: 10.1080/15257770600890814

Genes

TPMT
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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