Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

doi:10.1083/jcb.112.5.1041

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Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

The Journal of cell biology - 1 Mar 1991

Turley E A, Austen L, Vandeligt K, Clary C

Abstract excerpt

Hyaluronan (HA) and one of its cell binding sites, fibroblast hyaluronan binding protein (HABP), is shown to contribute to the regulation of 10T1/2 cell locomotion that contain an EJ-ras-metallothionein (MT-1) hybrid gene. Promotion of the ras-hybrid gene with zinc sulfate acutely stimulates, by 6-10-fold, cell locomotion. After 10 h, locomotion drops to two- to threefold above that of uninduced cells. Several...

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Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

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Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.

Abstract excerpt

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