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Article

Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.

British journal of clinical pharmacology - 1 Apr 2007

Zgheib N K, Frye R F, Tracy T S, Romkes M, Branch R A

Abstract excerpt

AIMS: We investigated flurbiprofen pharmacokinetics in 12 volunteers to develop a phenotypic trait measure that correlates with the fractional clearance to 4'-hydroxyflurbiprofen. The effect of the CYP2C9 inhibitor fluconazole on flurbiprofen metabolism was also evaluated. METHODS: Flurbiprofen pharmacokinetics were evaluated before and after the first and seventh doses of fluconazole. The urinary recovery ratio...

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Identifiers

PMID: 17054666
DOI: 10.1111/j.1365-2125.2006.02781.x
PMCID: PMC2203231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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