Article
Finding consistent gene transmission patterns on large and complex pedigrees.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Pirinen Matti, Gasbarra Dario
Abstract excerpt
A heuristic algorithm for finding gene transmission patterns on large and complex pedigrees with partially observed genotype data is proposed. The method can be used to generate an initial point for a Markov chain Monte Carlo simulation or to check that the given pedigree and the genotype data are consistent. In small pedigrees, the algorithm is exact by exhaustively enumerating all possibilities, but, in large...
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