Article
Novel heteroduplex method using small cytology specimens with a remarkably high success rate for analysing EGFR gene mutations with a significant correlation to gefitinib efficacy in non-small-cell lung cancer.
British journal of cancer - 23 Oct 2006
Oshita F, Matsukuma S, Yoshihara M, Sakuma Y, Ohgane N, Kameda Y, Saito H, Yamada K, Tsuchiya E, Miyagi Y
Abstract excerpt
We conducted a feasibility study to examine whether small numbers of cancer cells could be utilised for analysis of the EGFR gene status using the loop-hybrid mobility shift assay, which is a modified heteroduplex technique. Cytology specimens obtained by transbronchial abrasion were successfully...
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