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Article

Negative correlation of G+C content at silent substitution sites between orthologous human and mouse protein-coding sequences.

DNA research : an international journal for rapid publication of reports on genes and genomes - 31 Aug 2006

Takahashi Naoki, Nakashima Hiroshi

Abstract excerpt

We conducted a genome-wide analysis of variations in guanine plus cytosine (G+C) content at the third codon position at silent substitution sites of orthologous human and mouse protein-coding nucleotide sequences. Alignments of 3776 human protein-coding DNA sequences with mouse orthologs having >50 synonymous codons were analyzed, and nucleotide substitutions were counted by comparing sequences in the alignments...

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PMID: 17046958
DOI: 10.1093/dnares/dsl007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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