Article
Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder.
Neuroscience letters - 30 Jun 2010
Walker Rosie M, Christoforou Andrea, Thomson Pippa A, McGhee Kevin A, Maclean Alan, Mühleisen Thomas W, Strohmaier Jana, Nieratschker Vanessa, Nöthen Markus M, Rietschel Marcella, Cichon Sven, Morris Stewart W, Jilani Omer, Stclair David, Blackwood Douglas H, Muir Walter J, Porteous David J, Evans Kathryn L
Abstract excerpt
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe heritable psychiatric disorders involving a complex genetic aetiology. Neuregulin 1 (NRG1) is a leading candidate gene for SCZ, and has recently been implicated in BPD. We previously reported association of two NRG1 haplotypes with SCZ and BPD in a Scottish case-control sample. One haplotype is located at the 5' end of the gene (region A), and the other is...
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