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Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A <sub>2</sub>

17 Oct 2006

Abstract excerpt

The molecular basis of pathogen clone emergence is relatively poorly understood. Acquisition of a bacteriophage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated in the rapid emergence in the mid-1980s of a new hypervirulent clone of serotype M3 group A Streptococcus. Although several lines of circumstantial evidence suggest that SlaA is a virulence factor, this issue...

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PMID: 17043230
DOI: 10.1073/pnas.0607669103

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