Article
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Biochemistry - 24 Oct 2006
Comoletti Davide, Flynn Robyn E, Boucard Antony A, Demeler Borries, Schirf Virgil, Shi Jianxin, Jennings Lori L, Newlin Helen R, Südhof Thomas C, Taylor Palmer
Abstract excerpt
Neuroligins 1-4 are postsynaptic transmembrane proteins capable of initiating presynaptic maturation via interactions with beta-neurexin. Both neuroligins and beta-neurexins have alternatively spliced inserts in their extracellular domains. Using analytical ultracentrifugation, we determined that the extracellular domains of the neuroligins sediment as dimers, whereas the extracellular domains of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.