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Article

Striosomes and mood dysfunction in Huntington's disease.

Brain : a journal of neurology - 1 Jan 2007

Tippett Lynette J, Waldvogel Henry J, Thomas Sally J, Hogg Virginia M, van Roon-Mom Willeke, Synek Beth J, Graybiel Ann M, Faull Richard L M

Abstract excerpt

Variable phenotype is common in neurological disorders with single-gene inheritance patterns. In Huntington's disease, mood and cognitive symptoms are variably co-expressed with motor symptoms. There is also variable degeneration of neurons in the two major neurochemical compartments of the striatum, the striosomes and the extrastriosomal matrix. To determine whether the phenotypic variability in Huntington's...

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Identifiers

PMID: 17040921
DOI: 10.1093/brain/awl243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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