Article
Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure.
Cell death and differentiation - 1 Mar 2007
Perez G I, Acton B M, Jurisicova A, Perkins G A, White A, Brown J, Trbovich A M, Kim M-R, Fissore R, Xu J, Ahmady A, D'Estaing S G, Li H, Kagawa W, Kurumizaka H, Yokoyama S, Okada H, Mak T W, Ellisman M H, Casper R F, Tilly J L
Abstract excerpt
Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death. Using germ cells from inbred mouse strains, we found that apoptosis in mature (metaphase II) oocyte...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.