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Article

Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006

Chuma Shinichiro, Hosokawa Mihoko, Kitamura Kouichi, Kasai Shinya, Fujioka Makio, Hiyoshi Masateru, Takamune Kazufumi, Noce Toshiaki, Nakatsuji Norio

Abstract excerpt

Embryonic patterning and germ-cell specification in mice are regulative and depend on zygotic gene activities. However, there are mouse homologues of Drosophila maternal effect genes, including vasa and tudor, that function in posterior and germ-cell determination. We report here that a targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male...

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Identifiers

PMID: 17038506
DOI: 10.1073/pnas.0601878103
PMCID: PMC1635099

Genes

MTR
TDRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice.PMID 17038506Read ↗

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RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesisSemantic proximity Read ↗

Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: Domain composition, intracellular localization, and function in male germ cells in miceSemantic proximity Read ↗

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Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish.Semantic proximity Read ↗

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated MiwiSemantic proximity Read ↗

Multiple domains of scaffold Tudor protein play nonredundant roles in Drosophila germline.Semantic proximity Read ↗

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The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte–embryo transitionSemantic proximity Read ↗

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