Article
Multiple domains of scaffold Tudor protein play nonredundant roles in Drosophila germline.
Life science alliance - 1 Oct 2025
Tindell Samuel J, Boeving Alyssa G, Aebersold Julia, Arkov Alexey L
Abstract excerpt
Scaffold proteins play crucial roles in subcellular organization and function. In many organisms, proteins with multiple Tudor domains are required for the assembly of membraneless RNA-protein organelles (germ granules) in germ cells. Tudor domains are protein-protein interaction modules which bind to methylated polypeptides. Drosophila Tudor protein contains 11 Tudor domains, which is the highest number known in...
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