Article
Glycosylation governs the binding of antipeptide antibodies to regions of hypervariable amino acid sequence within recombinant gp120 of human immunodeficiency virus type 1.
The Journal of general virology - 1 Dec 1990
Davis D, Stephens D M, Willers C, Lachmann P J
Abstract excerpt
Antibodies raised to an overlapping series of peptides following the amino acid sequence of the external envelope glycoprotein (gp 120) of human immunodeficiency virus type 1 (HIV-1) recognize eight regions in recombinant gp 120 molecules. If the recombinant molecules are glycosylated, three of these regions show a reduced capacity to bind antibody. Of the other five regions, two are strain-specific and...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Antibody Reactions
- Epitopes
- Genetic Variation
- Glycosylation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Humans