Article
Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms.
British journal of cancer - 20 Nov 2006
Walker C, Haylock B, Husband D, Joyce K A, Fildes D, Jenkinson M D, Smith T, Broome J, Kopitzki K, du Plessis D G, Prosser J, Vinjamuri S, Warnke P C
Abstract excerpt
The -1p/-19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated the predictive and prognostic significance of pretherapy (201)Tl and (18)F-FDG SPECT and genotype in 38 primary and 10 recurrent oligodendroglial neoplasms following PCV chemotherapy. 1p/19q loss was seen in...
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