Article
Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.
AJNR. American journal of neuroradiology - 1 Aug 2013
Chawla S, Krejza J, Vossough A, Zhang Y, Kapoor G S, Wang S, O'Rourke D M, Melhem E R, Poptani H
Abstract excerpt
BACKGROUND AND PURPOSE: Oligodendrogliomas with 1p/19q chromosome LOH are more sensitive to chemoradiation therapy than those with intact alleles. The usefulness of dynamic susceptibility contrast-PWI-guided ¹H-MRS in differentiating these 2 genotypes was tested in this study. MATERIALS AND METHODS: Forty patients with oligodendrogliomas, 1p/19q LOH (n = 23) and intact alleles (n = 17), underwent MR imaging and...
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