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Article

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

Gastroenterology - 1 Oct 2006

McGovern Dermot P B, Butler Helen, Ahmad Tariq, Paolucci Marta, van Heel David A, Negoro Kenichi, Hysi Pirro, Ragoussis Jiannis, Travis Simon P L, Cardon Lon R, Jewell Derek P

Abstract excerpt

BACKGROUND & AIMS: The identification of the association between Crohn's disease (CD) and NOD2 (CARD15) confirmed both the heritability of CD and highlighted the role of the nuclear factor kappaB (NFkappaB) pathway in disease pathogenesis. Other susceptibility loci exist. TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q. TUCAN is expressed in the gut and is a negative regulator of NFkappaB,...

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Source

Identifiers

PMID: 17030188
DOI: 10.1053/j.gastro.2006.08.008

Genes

NOD2
CARD8
NOD1
TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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