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Article

Atomic force microscopy reveals DNA bending during group II intron ribonucleoprotein particle integration into double-stranded DNA.

Biochemistry - 17 Oct 2006

Noah James W, Park Soyeun, Whitt Jacob T, Perutka Jiri, Frey Wolfgang, Lambowitz Alan M

Abstract excerpt

The mobile Lactococcus lactis Ll.LtrB group II intron integrates into DNA target sites by a mechanism in which the intron RNA reverse splices into one DNA strand while the intron-encoded protein uses a C-terminal DNA endonuclease domain to cleave the opposite strand and then uses the cleaved 3' end to prime reverse transcription of the inserted intron RNA. These reactions are mediated by an RNP particle that...

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Identifiers

PMID: 17029398
DOI: 10.1021/bi060612h
PMCID: PMC2526057

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