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Article

Analysis of formaldehyde-induced Adh mutations in Drosophila by RNA structure mapping and direct sequencing of PCR-amplified genomic DNA.

Biochemical genetics - 1 Aug 1990

Le L, Ayer S, Place A R, Benyajati C

Abstract excerpt

Two formaldehyde-induced mutations at the Drosophila Adh locus (Adhfn45 and Adhfn46) were analyzed by determining RNA structures at different developmental stages, polymerase chain reaction (PCR) amplification of the affected genomic regions, and direct sequencing of the resulting double-stranded DNA fragments. Adhfn46 adults and larvae accumulate abundant ADH-like distal (adult) and proximal (larval) transcripts...

Topics

Alcohol Dehydrogenase
Amino Acid Sequence
Animals
Base Sequence
DNA
Drosophila
Formaldehyde
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

Restriction Mapping

Source

Identifiers

PMID: 1702621
DOI: 10.1007/BF02401426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702621-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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