Thyroid-specific T cells in the normal Wistar rat. II. T cell clones interact with cloned wistar rat thyroid cells and provide direct evidence for autoantigen presentation by thyroid epithelial cells.

doi:10.1016/0090-1229(91)90136-x

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Article

Thyroid-specific T cells in the normal Wistar rat. II. T cell clones interact with cloned wistar rat thyroid cells and provide direct evidence for autoantigen presentation by thyroid epithelial cells.

Clinical immunology and immunopathology - 1 Feb 1991

Kimura H, Davies T F

Abstract excerpt

Strains of rat differ in their susceptibility to experimental autoimmune thyroiditis (EAT). We recently observed that the normal Wistar rat has lymph node (LN) T cells which recognize the newly available cloned Wistar thyroid cell line (WRT) and/or rat thyroglobulin (rTg). We have now cloned thyroid-specific T cells and characterized their interaction with the WRT target cell. Twenty-three T cell clones were...

Topics

Animals
Antigen-Presenting Cells
Autoantigens
Cell Communication
Cell Division
Cell Membrane
Clone Cells
Epitopes
Female
Interferon-gamma
Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Histocompatibility Complex

Phenotype

Rats

T-Lymphocytes

Thyroglobulin

Thyroid Gland

Thyroiditis, Autoimmune

Source

Open in PubMed

Identifiers

PMID: 1702377
DOI: 10.1016/0090-1229(91)90136-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702377-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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