Article
Cytotoxic chemotherapy induces cell differentiation in small-cell lung carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 1991
Brambilla E, Moro D, Gazzeri S, Brichon P Y, Nagy-Mignotte H, Morel F, Jacrot M, Brambilla C
Abstract excerpt
Despite the high response rates resulting from chemotherapy, the majority of small-cell lung cancer (SCLC) patients relapse with chemoresistant tumors. To analyze the phenotypic changes that are precursors of chemoresistant status, and to investigate the role of chemotherapy in these changes, tum...
Topics
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma, Small Cell
- Cell Differentiation
- Cyclophosphamide
- Cytoplasmic Granules
- Desmosomes
- Doxorubicin
- Drug Resistance
- Etoposide
- Female
- Humans
- Immunohistochemistry
- Keratins
- Lung Neoplasms
- Lymphatic Metastasis
- Male
- Middle Aged