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Article

The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo.

Development (Cambridge, England) - 1 Nov 2006

Lyczak Rebecca, Zweier Lynnsey, Group Thomas, Murrow Mary Ann, Snyder Christine, Kulovitz Lindsay, Beatty Alexander, Smith Kristen, Bowerman Bruce

Abstract excerpt

In the nematode Caenorhabditis elegans, sperm entry into the oocyte triggers the completion of meiosis and the establishment of the embryonic anteroposterior (AP) axis. How the early embryo makes the transition from a meiotic to a mitotic zygote and coordinates cell cycle changes with axis formation remains unclear. We have discovered roles for the C. elegans puromycin-sensitive aminopeptidase PAM-1 in both cell...

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Identifiers

PMID: 17021038
DOI: 10.1242/dev.02615

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo.PMID 17021038Read ↗

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.Semantic proximity Read ↗

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Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.Semantic proximity Read ↗

Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.Semantic proximity Read ↗

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The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans.Semantic proximity Read ↗

The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.Semantic proximity Read ↗

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