Article
RNA-Mediated interference of a cdc25 homolog in Caenorhabditis elegans results in defects in the embryonic cortical membrane, meiosis, and mitosis.
Developmental biology - 1 Feb 1999
Ashcroft N R, Srayko M, Kosinski M E, Mains P E, Golden A
Abstract excerpt
The CDC25 dual-specificity phosphatase family has been shown to play a key role in cell cycle regulation. The phosphatase activity of CDC25 drives the cell cycle by removing inhibitory phosphates from cyclin-dependent kinase/cyclin complexes. Although the regulation of CDC25 phosphatase activity...
Topics
- Animals
- Caenorhabditis elegans
- Cell Cycle Proteins
- Cell Membrane
- Embryonic Development
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Immunohistochemistry
- Meiosis
- Microscopy, Fluorescence
- Microscopy, Video
- Mitosis
- Phenotype
- Phosphoprotein Phosphatases
- Ploidies
- RNA, Messenger
- cdc25 Phosphatases