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Article

Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.

Development (Cambridge, England) - 1 Apr 2003

Shakes Diane C, Sadler Penny L, Schumacher Jill M, Abdolrasulnia Maziar, Golden Andy

Abstract excerpt

In C. elegans, mutants in the anaphase-promoting complex or cyclosome (APC/C) exhibit defects in germline proliferation, the formation of the vulva and male tail, and the metaphase to anaphase transition of meiosis I. Oocytes lacking APC/C activity can be fertilized but arrest in metaphase of meiosis I and are blocked from further development. To examine the cell cycle and developmental consequences of reducing...

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Identifiers

PMID: 12620985
DOI: 10.1242/dev.00385
PMCID: PMC1805483

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APC

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Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.PMID 12620985Read ↗

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.Semantic proximity Read ↗

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emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.Semantic proximity Read ↗

Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis.Semantic proximity Read ↗

Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.Semantic proximity Read ↗

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