Article
The pedigree analysis and prenatal diagnosis of Hong Kongαα Thalassemia and the sequence analysis of Hong Kongαα Allele.
Molecular genetics & genomic medicine - 1 Jul 2020
Wang Wenjuan, Zheng Haiqing, Zeng Dan, Jiang Linbin, Yu Donglan, Yang Yuzhong, Feng Qiao, Xia Yang, Zhu Chunjiang
Abstract excerpt
BACKGROUND: Thalassemia is one of the most common monogenic hemolytic disorders in the world. Hong Kongαα (HKαα) thalassemia was initially found among the people of southern China. Because of the complexity of genetic changes in HKαα thalassemia, we lack a precise sequence analysis of the HKαα allele. Here we aim to detect the specific genotype and trace the law of inheritance of this rare genotype. METHODS: We...
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