Article
Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease.
Neuroscience letters - 20 Nov 2006
Ramos María C, Tenorio Raquel, Martínez-García Ana, Sastre Isabel, Vilella-Cuadrada Elisabet, Frank Ana, Rosich-Estragó Marcel, Valdivieso Fernando, Bullido María J
Abstract excerpt
Alzheimer's disease (AD) is a complex multifactorial disorder involving a number of genetic and environmental factors, with severe head injury consistently reported as a major non-genetic risk factor. The adrenergic activation that occurs during major trauma increases cAMP levels, therefore the cAMP signaling pathway might be involved in AD pathogenesis. Time course of candidate gene expression following...
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