Article
Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis.
The American journal of psychiatry - 1 Jul 2007
Matsuzawa Daisuke, Hashimoto Kenji, Miyatake Ryosuke, Shirayama Yukihiko, Shimizu Eiji, Maeda Kazuhisa, Suzuki Yoichi, Mashimo Yoichi, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Hata Akira, Sawa Akira, Iyo Masaomi
Abstract excerpt
OBJECTIVE: Protein interacting with C-kinase-1 (PICK1) plays a role in the targeting and clustering of dopamine transporter, which is the primary target site for the abused drug methamphetamine. Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers. METHOD: The authors studied the association...
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