Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRYAB promoter polymorphisms: influence on multiple sclerosis susceptibility and clinical presentation.

Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2007

Stoevring Birgitte, Frederiksen Jette L, Christiansen Michael

Abstract excerpt

BACKGROUND: alphaB-crystallin is a molecular chaperone and potential myelin antigen, up-regulated in the earlier stages of multiple sclerosis (MS) lesions. In the alphaB-crystallin gene (CRYAB), single nucleotide polymorphisms (SNPs) have been associated with MS susceptibility (g.CRYAB-652A>G) and a rapidly progressive clinical course (g.CRYAB-650C>G). METHOD: CRYAB was screened for mutations in 233 MS patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Crystallin B Chain
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Denmark

Share to Genetic Predisposition to Disease

Share to Multiple Sclerosis

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17010329
DOI: 10.1016/j.cca.2006.06.017

Genes

CRYAB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

CRYAB promoter polymorphisms: influence on multiple sclerosis susceptibility and clinical presentation.PMID 17010329Read ↗

[Alpha]B-crystallin genotype has impact on the multiple sclerosis phenotype.Semantic proximity Read ↗

CRYAB-650 C>G (rs2234702) affects susceptibility to Type 1 diabetes and IAA-positivity in Swedish population.Semantic proximity Read ↗

Multi-system neurological disorder associated with a CRYAB variant.Semantic proximity Read ↗

Five novel genetic variants in the promoter and coding region of the alpha B-crystallin gene (CRYAB): -652G>A, -650C>G, -249G>C, S41Y, P51L.Semantic proximity Read ↗

Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin.Semantic proximity Read ↗

A novel dominant mutation in CRYAB gene leading to a severe phenotype with childhood onset.Semantic proximity Read ↗

Association of Alpha B-Crystallin (CRYAB) genotypes with breast cancer susceptibility in Taiwan.Semantic proximity Read ↗

Pharmacogenetic Predictors of Response to Interferon Beta Therapy in Multiple Sclerosis.Semantic proximity Read ↗

Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.Semantic proximity Read ↗

A novel CRYAB mutation resulting in multisystemic disease.Semantic proximity Read ↗

Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.