Article
[Alpha]B-crystallin genotype has impact on the multiple sclerosis phenotype.
Neurology - 11 Nov 2003
van Veen T, van Winsen L, Crusius J B A, Kalkers N F, Barkhof F, Peña A S, Polman C H, Uitdehaag B M J
Abstract excerpt
BACKGROUND: Both multiple sclerosis (MS) susceptibility and MS clinical phenotype are in part genetically determined. [Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G. METHODS: These polymorphisms were studied in sporadic cases of MS, assessing disease susceptibility, clinical...
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