Article
The host's genetic background determines the extent of angiogenesis induced by schistosome egg antigens.
Acta tropica - 1 Oct 2006
Van de Vijver Koen K, Colpaert Cecile G, Jacobs Werner, Kuypers Kristel, Hokke Cornelis H, Deelder André M, Van Marck Eric A
Abstract excerpt
Schistosomiasis is characterised by periovular granuloma formation within the portal tract and presinusoidal venules. As inflammation wanes, continued attempts to wall off and repair hepatic injury, lead to the development of extensive fibrosis. The codependence of chronic inflammation and angiogenesis is a well-known phenomenon. Neovascularisation is a complex process of endothelial cell proliferation and...
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