Article
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
PLoS neglected tropical diseases - 1 Jan 2021
Takaki Kevin K, Roca Francisco J, Schramm Gabriele, Wilbers Ruud H P, Ittiprasert Wannaporn, Brindley Paul J, Rinaldi Gabriel, Berriman Matthew, Ramakrishnan Lalita, Pagán Antonio J
Abstract excerpt
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of active investigation. Some studies in mice implicate Tumor Necrosis Factor (TNF) produced in response to the infection whereas others fail to find a role for it. In addition, in the mouse...
Topics
- Animals
- Antigens, Helminth
- Glycoproteins
- Granuloma
- Helminth Proteins
- Larva
- Macrophages
- Mutation
- Ovum
- Receptors, Tumor Necrosis Factor, Type I
- Ribonucleases
- Schistosoma mansoni
- Schistosomiasis mansoni