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Article

Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.

Experimental parasitology - 1 Apr 2010

Anthony Barrie, Mathieson William, de Castro-Borges William, Allen Jeremy

Abstract excerpt

Eggs of Schistosoma mansoni trapped in human liver can lead to fibrosis. Since liver fibrosis requires activation of hepatic stellate cells (HSC) from a quiescent to a myofibroblastic phenotype, we investigated the effects of S. mansoni eggs on this process using in vitro co-cultures with human HSC and evaluated established biomarkers for activation and fibrosis. HSC demonstrate significantly reduced expression...

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Source

Identifiers

PMID: 20045695
DOI: 10.1016/j.exppara.2009.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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