Article
Variable resistance to palivizumab in cotton rats by respiratory syncytial virus mutants.
The Journal of infectious diseases - 1 Dec 2004
Zhao Xiaodong, Chen Fu-Ping, Megaw A George, Sullender Wayne M
Abstract excerpt
BACKGROUND: Palivizumab (PZ) is the only monoclonal antibody in use against a human infectious disease. PZ is given as prophylaxis against infection with respiratory syncytial virus (RSV). An RSV escape mutant, MP4, has been shown to resist PZ prophylaxis in cotton rats. METHODS: To further defin...
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