Article
Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease.
Thrombosis and haemostasis - 1 Oct 2006
Lekakis John P, Ikonomidis Ignatios, Tsibida Maria, Protogerou Athanasios, Papada Aggeliki, Papapanagiotou Aggeliki, Revela Ioanna, Papamichael Christos M, Kalofoutis Anastasios T, Kremastinos Dimitrios T
Abstract excerpt
It was the objective of this study to investigate the relation between nitric oxide synthase (NOS3) gene polymorphisms, vascular inflammation, endothelial function, and atherosclerosis. We examined the effects of a variable nucleotide tandem repeats (VNTR) in intron 4, G894T in exon 7 and T-786C at the promoter region of NOS3 on i) C-reactive protein (CRP) and macrophage-colony stimulating-factor (MCSF), and ii)...
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