Article
Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2006
Lopez-Vergès Sandra, Camus Grégory, Blot Guillaume, Beauvoir Roxane, Benarous Richard, Berlioz-Torrent Clarisse
Abstract excerpt
The presence of the envelope glycoprotein Env in HIV-1 virions is essential for infectivity. To date, the molecular mechanism by which Env is packaged into virions has been largely unknown. Here, we show that TIP47 (tail-interacting protein of 47 kDa), which has been shown to interact with Env, also binds the MA (matrix) domain of HIV-1 Gag protein and that these three proteins form a ternary complex. Mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.