Article
Mixture models of serum iron measures in population screening for hemochromatosis and iron overload.
Translational research : the journal of laboratory and clinical medicine - 1 Oct 2006
McLaren Christine E, Li Kuo-Tung, McLaren Gordon D, Gordeuk Victor R, Snively Beverly M, Reboussin David M, Barton James C, Acton Ronald T, Dawkins Fitzroy W, Harris Emily L, Eckfeldt John H, Moses Godfrey C, Adams Paul C
Abstract excerpt
Homozygosity for the C282Y mutation of the hemochromatosis gene on chromosome 6p (HFE) is a common genetic trait that increases susceptibility to iron overload. The authors describe and apply methodology developed for the analysis of phenotypic and genotypic data from 46,136 non-Hispanic Caucasians, a subset of the multi-ethnic cohort enrolled in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. For...
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