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Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

29 Aug 2016

Abstract excerpt

Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological levels to low doses of the DNMTi 5-aza-2'-deoxycytidine (5-aza-CdR), there is a synergistic inhibition of cancer-cell...

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PMID: 27573823
DOI: 10.1073/pnas.1612262113

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