Article
A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention.
Biological psychiatry - 15 Sept 2006
Liu Yu-Li, Fann Cathy Shen-Jang, Liu Chih-Min, Chen Wei J, Wu Jer-Yuarn, Hung Shuen-Iu, Chen Chun-Houh, Jou Yuh-Shan, Liu Shih-Kai, Hwang Tzung-Jeng, Hsieh Ming H, Ouyang Wen-Chen, Chan Hung-Yu, Chen Jiann-Jyh, Yang Wei-Chih, Lin Chin-Yu, Lee Sandy F C, Hwu Hai-Gwo
Abstract excerpt
BACKGROUND: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. METHODS: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was >10%. Forty-seven...
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