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Article

Type IV pili-mediated secretion modulates Francisella virulence.

Molecular microbiology - 1 Oct 2006

Hager Anthony J, Bolton Diana L, Pelletier Mark R, Brittnacher Mitchell J, Gallagher Larry A, Kaul Rajinder, Skerrett Shawn J, Miller Samuel I, Guina Tina

Abstract excerpt

Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to identify seven F. novicida secreted proteins and the corresponding Type IV pilus (T4P) secretion...

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PMID: 16987180
DOI: 10.1111/j.1365-2958.2006.05365.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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