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Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells

1 Nov 2004

Abstract excerpt

The platinum compound oxaliplatin has been shown to be an effective chemotherapeutic agent for the treatment of colorectal cancer. In this study, we investigate the molecular mechanisms of action of oxaliplatin to identify means of predicting response to this agent. Exposure of colon cancer cells to oxaliplatin resulted in G2/M arrest and apoptosis. Immunofluorescent staining demonstrated that the apoptotic...

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PMID: 15545975
DOI: 10.1038/sj.bjc.6602215

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