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Article

Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation

1 Jan 2008

Abstract excerpt

Preclinical studies have demonstrated that the chemotherapeutic action of oxaliplatin, a third generation platinum derivative, is improved when combined with cetuximab, a monoclonal antibody inhibitor of epidermal growth factor receptors. To explore the mechanism of this synergistic benefit, we used HCT-8 and HCT-116, two human colon cancer cell lines, respectively, responsive and non-responsive to the...

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PMID: 18182978
DOI: 10.1038/sj.bjc.6604134

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