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Cystathionine β-synthase is essential for female reproductive function

19 Sept 2006

Abstract excerpt

In human reproduction, hyperhomocysteinemia has been reported as a risk factor for early pregnancy loss and congenital birth defects. Hyperhomocysteinemia is also recognized as a cause of maternal obstetric complications such as preeclampsia. The role of plasma hyperhomocysteinemia in female fertility was examined using cystathionine beta synthase knockout (cbs KO) mice. Cbs KO females were infertile, showed...

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PMID: 16984962
DOI: 10.1093/hmg/ddl393

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