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Article

Association of insulin-like growth factor-1 receptor polymorphism in dementia.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Garcia J, Ahmadi A, Wonnacott A, Sutcliffe W, Nagga K, Soderkvist P, Marcusson J

Abstract excerpt

There is an increasing interest in how oxidative stress can cause cells to go into apoptosis in both normal ageing and in neurodegenerative disorders. Previous research has implicated insulin-like growth factor-1 (IGF-1) as being involved in the pathogenesis in Alzheimer's disease (AD) by protecting the neurons through reducing neuronal susceptibility to oxidative stress. IGF-1 receptor (IGF-1R) polymorphisms...

Topics

Aged
Alleles
Alzheimer Disease
DNA Primers
Dementia
Dementia, Vascular
Female
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, IGF Type 1

Severity of Illness Index

Source

Identifiers

PMID: 16983186
DOI: 10.1159/000095803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16983186-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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