Article
Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans.
Infection and immunity - 1 Dec 2006
Nishikubo Shuichi, Ohara Masaru, Ikura Masae, Katayanagi Katsuo, Fujiwara Tamaki, Komatsuzawa Hitoshi, Kurihara Hidemi, Sugai Motoyuki
Abstract excerpt
Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.
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