Article
Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity.
Journal of clinical microbiology - 1 May 2006
Friedrich Alexander W, Lu Shan, Bielaszewska Martina, Prager Rita, Bruns Phillip, Xu Jian-Guo, Tschäpe Helmut, Karch Helge
Abstract excerpt
We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even...
Topics
- Alleles
- Bacterial Toxins
- Base Sequence
- Cell Line
- Conserved Sequence
- DNA, Bacterial
- Diarrhea
- Endothelium, Vascular
- Escherichia coli Infections
- Escherichia coli O157
- Evolution, Molecular
- Genes, Bacterial
- Hemolytic-Uremic Syndrome