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Article

Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity.

Journal of clinical microbiology - 1 May 2006

Friedrich Alexander W, Lu Shan, Bielaszewska Martina, Prager Rita, Bruns Phillip, Xu Jian-Guo, Tschäpe Helmut, Karch Helge

Abstract excerpt

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even...

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Identifiers

PMID: 16672418
DOI: 10.1128/JCM.44.5.1844-1846.2006
PMCID: PMC1479162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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