Article
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.
Genes & development - 15 Sept 2006
Krishnamoorthy Thanuja, Chen Xin, Govin Jerome, Cheung Wang L, Dorsey Jean, Schindler Karen, Winter Edward, Allis C David, Guacci Vincent, Khochbin Saadi, Fuller Margaret T, Berger Shelley L
Abstract excerpt
Sporulation in Saccharomyces cerevisiae is a highly regulated process wherein a diploid cell gives rise to four haploid gametes. In this study we show that histone H4 Ser1 is phosphorylated (H4 S1ph) during sporulation, starting from mid-sporulation and persisting to germination, and is temporally distinct from earlier meiosis-linked H3 S10ph involved in chromosome condensation. A histone H4 S1A substitution...
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