Article
Gene-environment interactions in complex diseases: genetic models and methods for QTL mapping in multiple half-sib populations.
Genetical research - 1 Oct 2006
Kadarmideen Haja N, Li Yongjun, Janss Luc L G
Abstract excerpt
An interval quantitative trait locus (QTL) mapping method for complex polygenic diseases (as binary traits) showing QTL by environment interactions (QEI) was developed for outbred populations on a within-family basis. The main objectives, within the above context, were to investigate selection of genetic models and to compare liability or generalized interval mapping (GIM) and linear regression interval mapping...
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