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Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

13 Sept 2006

Abstract excerpt

Estrogen reduces brain injury after experimental cerebral ischemia in part through a genomic mechanism of action. Using DNA microarrays, we analyzed the genomic response of the brain to estradiol, and we identified a transcript, cocaine- and amphetamine-regulated transcript (CART), that is highly induced in the cerebral cortex by estradiol under ischemic conditions. Using in vitro and in vivo models of neural...

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PMID: 16971488
DOI: 10.1073/pnas.0602932103

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