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Genetic and functional analyses of the lgtH gene, a member of the beta-1,4-galactosyltransferase gene family in the genus Neisseria.

Microbiology (Reading, England) - 1 Jan 2006

Zhu Peixuan, Boykins Robert A, Tsai Chao-Ming

Abstract excerpt

Lipooligosaccharide (LOS) is a major virulence factor of the pathogenic Neisseria. Three galactosyltransferase genes, lgtB, lgtE and lgtH, responsible for the biosynthesis of LOS oligosaccharide chains, were analysed in five Neisseria species. The function of lgtH in Neisseria meningitidis 6,275 was determined by mutagenesis and chemical characterization of the parent and mutant LOS chains. The chemical...

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PMID: 16385122
DOI: 10.1099/mic.0.28327-0

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