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Article

Heterozygosity for a Mendelian disorder as a risk factor for complex disease.

Clinical genetics - 1 Oct 2006

Sidransky E

Abstract excerpt

While genetic diseases are generally classified as being either 'simple' monogenic or 'complex' polygenic, the distinction between Mendelian and complex disorders is becoming increasingly blurred. Mendelian disorders may demonstrate qualities more typical of multifactorial diseases through shared clinical presentations, the effect of genetic modifiers, moonlighting proteins, synergistic heterozygosity, disease...

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PMID: 16965318
DOI: 10.1111/j.1399-0004.2006.00688.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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